产品货号：
Z30064
中文名称：
CUL3抗体
英文名称：
Anti-CUL3 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CUL3 Antibody |
| 指标别名 | CUL 3;CUL3;cullin 3;KIAA0617 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | IHC,IP,WB |
| 基因名称 | CUL3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Cul3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the N-Terminal near amino acids 1-25 of Human Cul3 coupled to KLH. |
| 成分 | 0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-Cul3 antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.This product reacts with human Cullin 3.Cross-reactivity is expected against mouse Cul3 based on sequence homology.Cross-reactivity with other human cullins is unlikely based on sequence homology. |
| 浓度 | 85mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store anti-Cul3 at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Cul3 antibody is ideal for Cell Biology,Cancer and Ubiquitin research.Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination,as well as binding to various specificity factors to recruit substrates.Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex,which mediates the ubiquitination of proteins involved in cell cycle progression,signal transduction and transcription.In the SCF complex,cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.Unlike Cul1 and Cul2,Cul3 seems not to be a part of the SCF complex consisting of CUL1,RBX1,SKP1 and SKP2.Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1,Cyclin E and RBX1. |
| Uniprot ID | Q13618 |
| 推荐稀释比 | ELISA:1:2,000 - 1:10,000 IHC:User Optimized IP:1:100 WB:1:500 - 1:1,000 |
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